Endocrine Abstracts

Leptin, adiponectin and resistin play an essential role in regulation of body mass, which is controlled by thyroid hormones levels.The aim of the study was to evaluate leptin, adiponectin and resistin levels in young patients with Graves’ disease and in children with Hashimoto’s thyroiditis.The study group formed 78 patients suffering from Graves’ disease (30 girls and 2 boys; aged from 6 to 21- mean 15.2 years) and ...

Thyroid disease let to change of weight – in hyperthyroid body mass is reduced, but in hypothyroid it is increased. Recently researches suggest that many new bioactive substances, like ghrelin and obestatin, play a role in regulation of body mass. These closely related hormones have paradoxically different effects- ghrelin increases, but obestatin decreases appetite. The aim of the study was to evaluate ghrelin and obestatin levels in young patients with untreated Graves&...

Forkhead box P3 (Foxp3) is an important regulatory factor for the development and function of T regulatory cells (Tregs). Moreover it has been established that deficiency of the Foxp3 gene in Treg cells suppresses their regulatory function leading to the development of autoimmune thyroid diseases (AITDs). The aim of our study was to estimate the association of three polymorphism of FOXP3 gene with the predisposition to GD and HT in children.<p class="abst...